Scientific articles illustrated on video

Application of adult-derived human satellite cells

Journal of Clinical Investigation

Simone Spuler, Helena Escobar and Andreas Marg demonstrate that satellite cells can be successfully expanded from human adult muscle biopsies in culture and transplantation of satellite cell-containing human muscle fiber fragments into irradiated mice restores damaged muscle tissue.

Original paper: Marg A, Escobar H, Gloy S, Kufeld M, Zacher J, Spuler A, Birchmeier C, Izsvák Z, Spuler S. Human satellite cells have regenerative capacity and are genetically manipulable. J Clin Invest. 2014 Aug 26.

Dysferlin-peptides reallocate mutated dysferlin thereby restoring function

Public Library of Science one

Mutations in the dysferlin gene cause the most frequent adult-onset limb girdle muscular dystrophy, LGMD2B. Verena Schöwel explains an approach to relocate mutant dysferlin for restoration of its functionality using short peptides derived from dysferlin.

Original paper: Schoewel V, Marg A, Kunz S, Overkamp T, Siegert Carrazedo R, Zacharias U, Daniel PT, Spuler S. Dysferlin-Peptides Reallocate Mutated Dysferlin Thereby Restoring Function. PloS one. 2012;7(11):e49603