Header Deubzer
© Hedwig Deubzer, ECRCV, Charite

Deubzer Lab

Epigenetic Modifications in Neuroblastoma

My lab pursues Translational Neuroblastoma Research.
We focus on mechanisms that drive uncontrolled proliferation, mediate therapy resistance, block neuronal differentiation and promote the invasion-metastasis cascade by applying systems biology concepts to a solid basis of high-throughput molecular profiling data.

Preclinical neuroblastoma models include patient-derived 3D cell cultures and xenografts in mice. All research projects are directed towards providing a basis for decision-making in the rational development of improved diagnostics and novel therapeutics for high-risk neuroblastoma patients.

Further information could be found at the Charité website of the group at the Department of Pediatrics, Division of Oncology and Hematology.

Publications

/ J Allergy Clin Immunol

Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing

  • A. Rensing-Ehl
  • M.R. Lorenz
  • M. Führer
  • W. Willenbacher
  • E. Willenbacher
  • S. Sopper
  • M. Abinun
  • M.E. Maccari
  • C. König
  • P. Haegele
  • S. Fuchs
  • C. Castro
  • P. Kury
  • O. Pelle
  • C. Klemann
  • M. Heeg
  • J. Thalhammer
  • O. Wegehaupt
  • M. Fischer
  • S. Goldacker
  • B. Schulte
  • S. Biskup
  • P. Chatelain
  • V. Schuster
  • K. Warnatz
  • B. Grimbacher
  • A. Meinhardt
  • D. Holzinger
  • P.T. Oommen
  • T. Hinze
  • H. Hebart
  • K. Seeger
  • K. Lehmberg
  • T.R. Leahy
  • A. Claviez
  • S. Vieth
  • F.H. Schilling
  • I. Fuchs
  • M. Groß
  • F. Rieux-Laucat
  • A. Magerus
  • C. Speckmann
  • K. Schwarz
  • S. Ehl
/ Nat Commun

Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN

  • S. Fuchs
  • C. Danßmann
  • F. Klironomos
  • A. Winkler
  • J. Fallmann
  • L.M. Kruetzfeldt
  • A. Szymansky
  • J. Naderi
  • S.H. Bernhart
  • L. Grunewald
  • K. Helmsauer
  • E. Rodriguez-Fos
  • M. Kirchner
  • P. Mertins
  • K. Astrahantseff
  • C. Suenkel
  • J. Toedling
  • F. Meggetto
  • M. Remke
  • P.F. Stadler
  • P. Hundsdoerfer
  • H.E. Deubzer
  • A. Künkele
  • P. Lang
  • J. Fuchs
  • A.G. Henssen
  • A. Eggert
  • N. Rajewsky
  • F. Hertwig
  • J.H. Schulte
/ Pediatr Blood Cancer

Optimising urinary catecholamine metabolite diagnostics for neuroblastoma

  • Y.A.H. Matser
  • I.R.N. Verly
  • M. van der Ham
  • M.G.M. de Sain‐van der Velden
  • N.M. Verhoeven‐Duif
  • S. Ash
  • G. Cangemi
  • S. Barco
  • M.B. Popovic
  • A.B.P. van Kuilenburg
  • G.A.M. Tytgat
/ Nat Genet

Parallel sequencing of extrachromosomal circular DNAs and transcriptomes in single cancer cells

  • R. Chamorro González
  • T. Conrad
  • M.C. Stöber
  • R. Xu
  • M. Giurgiu
  • E. Rodriguez-Fos
  • K. Kasack
  • L. Brückner
  • E. van Leen
  • K. Helmsauer
  • H. Dorado Garcia
  • M.E. Stefanova
  • K.L. Hung
  • Y. Bei
  • K. Schmelz
  • M. Lodrini
  • S. Mundlos
  • H.Y. Chang
  • H.E. Deubzer
  • S. Sauer
  • A. Eggert
  • J.H. Schulte
  • R.F. Schwarz
  • K. Haase
  • R.P. Koche
  • A.G. Henssen
/ Pediatr Infect Dis J

Treatment of infants and children with SARS-CoV-2 monoclonal antibodies: a European case series

  • C. Rau
  • L. Auer-Hackenberg
  • H.E. Deubzer
  • E. Schwabel
  • M. Jaros
  • A. Diederichs
  • T. Lehrnbecher
  • M. Holm
  • M.L. von Linstow
  • L. Martin
  • S.S. Dinges
  • M. Rothensteiner
  • M. Siepermann
  • V. Strenger
  • U. von Both
  • N. Teig
  • F. Brinkmann
  • F. Leeb
  • M. Zeitlinger
  • R. Kobbe
  • F. Götzinger
/ Haematologica

Rituximab therapy after pediatric hematopoietic stem cell transplantation can cause prolonged B cell impairment and increases the risk for infections - a retrospective matched cohort study.

  • M. Launspach
  • D. Temel
  • E. Ohlendorf
  • F. Zirngibl
  • B. Materne
  • L. Oevermann
  • H.E. Deubzer
  • A.G. Henssen
  • A. Künkele
  • P. Hundsdörfer
  • H. von Bernuth
  • A. Pruß
  • A. Eggert
  • A. von Stackelberg
  • P. Lang
  • J.H. Schulte
/ Cancer Discov

A deep dive into the circulating ctDNA cosmos to vanquish neuroblastoma

  • H.E. Deubzer
  • K. Astrahantseff
  • M. Lodrini
/ Leukemia

Incidence of subsequent malignancies after total body irradiation-based allogeneic HSCT in children with ALL - long-term follow-up from the prospective ALL-SCT 2003 trial

  • A. Eichinger
  • U. Poetschger
  • E. Glogova
  • P. Bader
  • O. Basu
  • R. Beier
  • B. Burkhardt
  • C.F. Classen
  • A. Claviez
  • S. Corbacioglu
  • H.E. Deubzer
  • J. Greil
  • B. Gruhn
  • T. Güngör
  • K. Kafa
  • J.S. Kühl
  • P. Lang
  • B.S. Lange
  • R. Meisel
  • I. Müller
  • M.G. Sauer
  • P.G. Schlegel
  • A. Schulz
  • D. Stachel
  • B. Strahm
  • A. Wawer
  • C. Peters
  • M.H. Albert
/ Curr Oncol

Efficacy and feasibility of proton beam therapy in relapsed high-risk neuroblastoma-experiences from the prospective KiProReg registry

  • D. Jazmati
  • B. Hero
  • T.M. Thole-Kliesch
  • J. Merta
  • H.E. Deubzer
  • C. Bäumer
  • F. Heinzelmann
  • S.S. Schleithoff
  • F. Koerber
  • A. Eggert
  • R. Schwarz
  • T. Simon
  • B. Timmermann
/ Neuropathol Appl Neurobiol

Evidence of neural crest cell origin of a DICER1 mutant CNS sarcoma in a child with DICER1 syndrome and NRAS-mutant neurocutaneous melanosis

  • L. Schweizer
  • W. Hartmann
  • A. Koch
  • M. Nunninger
  • U.W. Thomale
  • V. Pennacchietti
  • A. Tietze
  • D. Horn
  • K.W. Pajtler
  • S. Hirsch
  • I. Wieland
  • H. Deubzer
  • R. Rossi
  • P. Hernáiz Driever
  • K. von Hoff
  • B. von Zezschwitz