Oertel Lab
Translational Neuroimmunology
Profile
We are a translational neuroimmunology lab at the Experimental and Clinical Research Center (ECRC) of the Max Delbrück Center and Charité Berlin. Combining animal models and clinical studies, we investigate neuroinflammatory disorders with emphasis on neuroprotection, imaging, and the visual system.
Neurodegeneration is the leading cause of functional decline in neuroinflammatory disorders. Initiated by neuroinflammation and/or demyelination, patients with multiple sclerosis (MS) and other neuroinflammatory disorders such as neuromyelitis optica spectrum disorders (NMOSD) undergo non-reversible neurodegeneration leading to major disability accrual. Although neuroinflammation and demyelination are targeted by existing or upcoming treatments, neurodegeneration can currently not be prevented or reversed. The goal of our lab is to identify characteristics of 1) neuronal vulnerability and of 2) innate immune cell activation that amplify neurodegeneration and can be therapeutically targeted. Our lab also contributes to 3) developing imaging markers for neurodegeneration in clinical trials.
The visual system offers a well-defined environment for these investigations due to various available innovative translational methods, a robust separation from nearby structures and clear structure-function-correlations. In our lab, we are combining advanced methods of preclinical (innovative mouse models, in vivo imaging, single-cell RNA sequencing) and clinical research (retinal imaging, artificial intelligence-based post-processing) in a unique translational approach to understand how we can reduce neurodegeneration and enhance neuroprotection in neuroinflammatory disorders.
Header image generated by DALL·E
Team
Optometrists
Charlotte Bereuter, BSc
Optometrist
Carla Leutloff, MSc
Optometrist
Lukas Reeß, MSc
Optometrist
Hendrik Schulz, MSc
Optometrist
Lab Manager
Mariam Salim, BSc
Lab Manager & Technical Assistance
Doctoral Students
Hadi Salih, MSc
PhD Student
Charité-Universitätsmedizin Berlin, Germany
Gilberto Solorza Buenrostro, MD MSc
PhD Student, PhD Program Medical Neurosciences
Charité-Universitätsmedizin Berlin, Germany
Emilio López Varela, MSc
PhD Student, CITIC Research Center
Universidade da Coruña, Spain
Yihan Wang, MSc
PhD Student, PhD Program Medical Neurosciences
Charité-Universitätsmedizin Berlin, Germany
Murat Delikaya, MD
Dr. med. Student
Charité-Universitätsmedizin Berlin, Germany
Lidia Kilinska, MD, Ophthalmologist
Dr. med. Student
Charité-Universitätsmedizin Berlin, Germany
Luca Magdalena Manthey
Dr. med. Student
Charité-Universitätsmedizin Berlin, Germany
Henriette Reinsberg
Dr. med. Student
Martin-Luther-Universität Halle-Wittenberg, Germany
Master Students
Juliette C Pesch, BSc
Master's Program in Molecular Medicine
Charité-Universitätsmedizin Berlin, Germany
Eugénie Rahier, BSc
Master's Program in Neuroscience
Université Paris Cité, Paris, France
Research Assistants
Bianca Knaack
Medical Student
Charité-Universitätsmedizin Berlin, Germany
Elisa Nowak
Medical Student
Charité-Universitätsmedizin Berlin, Germany
Johanna Reckzeh
Bachelor Student Optometry
BHT Berlin, Germany
Alumni
Gelsomina N Kaufhold, BSc (Lab Rotation, Master's Program in Molecular Medicine)
Laura K Ismajli, BSc (Lab Rotation, Master's Program in Medical Neurosciences)
Publications
News
Join us
Are you a bachelor or master student looking for an internship or thesis project? Are you planning to pursue a dissertation (PhD, MD/PhD, Dr. med.) or a postdoctoral fellowship? Whether you come from a clinical, computational or biology/neuroscience background: If you are interested in implementing translational projects, please contact us by email to discuss ideas.
