Science November 03, 2006 Natural Selection on Human MicroRNA Binding Sites Inferred from Single Nucleotide Polymorphism Data By combining SNP data with population genetics, MDC’s bioinformatics and systems biology expert...
Science October 09, 2006 Control of Peripheral Nerve Myelination by the β-Secretase BACE1 The protease BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) is essential for the...
Science September 25, 2006 Hematopoietic stem cell and multi lineage defects generated by constitutive β -catenin activation. The continuous regeneration of blood cells depends on the unique ability of few hematopoietic stem...
Science September 25, 2006 The Zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic b-cellsand intestinal endocrine cells Endocrine cells in the pancreas and intestine play key roles in nutritional homeostasis through the...
Science September 01, 2006 A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery A quality control system surveys the lumen of the endoplasmic reticulum (ER) for terminally...
Science May 22, 2006 M-line deficient titin causes cardiac lethality through impaired maturation of the sarcomere Titin is a giant muscle protein that forms a continuous filament system in both skeletal and cardiac...
Science May 11, 2006 An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis Arginine/lysine-rich motifs typically function as targeting signals for the translocation of...
Science May 11, 2006 The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment A specialized quality control system samples the endoplasmic reticulum (ER) for proteins that...
Science April 21, 2006 A structural role for ATP in the formation and stability of the human origin recognition complex In the yeast S. cerevisiae, origins of DNA replication are defined by the recruitment of the...
Science April 18, 2006 Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biochemical and ischemic stress The apoptosis-repressor-with-CARD (ARC) is a recently discovered anti-apoptotic factor with a highly...